VAXIMM is a privately held, clinical stage, Swiss/German biotech company developing oral T-cell immunotherapies for patients suffering from cancer.
VAXIMM’s technology is based on first-in-class oral T-cell activators using modified attenuated bacteria that can be readily adapted to target a wide range of cancer-related antigens.
The Company’s lead product candidate, oral VXM01, activates killer T-cells targeting tumor vasculature and certain immune-suppressive cells, thereby increasing immune cell infiltration in solid tumors.
VXM01 is currently in clinical development for several tumor types, including pancreatic, colorectal and brain cancer.
The Company has several additional product candidates at various stages of preclinical development targeting a variety of tumor targets and neoantigens.
VAXIMM has a collaboration agreement with Merck KGaA, Darmstadt, Germany and Pfizer Inc. to evaluate avelumab, a human anti-PD-L1 antibody, in combination with VXM01 in glioblastoma and colorectal cancer. The Company also has entered into a collaboration agreement with China Medical System Holdings (CMS), granting CMS full rights in China and other Asian countries (excluding Japan) to VAXIMM’s existing programs.
VAXIMM’s investors include BB Biotech Ventures, BioMed Partners, CMS, M Ventures and Sunstone Capital.
VAXIMM AG is headquartered in Basel, Switzerland. Its wholly owned subsidiary, VAXIMM GmbH, located in Mannheim, Germany, is responsible for the Company’s development activities.
VAXIMM has a strong management team of experienced leaders with outstanding scientific knowledge and medical development expertise.
Rainer Mück graduated from Otto-Friedrich-University Bamberg and holds a degree in business administration. He worked as a lecturer for business taxation at the Frankfurt School of Finance and Management in Frankfurt/Main and lectured on a variety of fiscal topics. Rainer Mück was also chairman of the tax commitee of the American Chamber of Commerce in Germany and as such represented foreign interests in Germany. He is a member of various supervisory boards in German und Swiss Corporations.
Prior to joining MPM in 2002, he was at Roche, where he served for nearly 20 years in several senior management positions in the global Pharma R&D organization, including VP and Director of the International Pharma Research Strategy Unit and Chief of Staff to the President of Roche Global R&D. He organized and served on the Global Board of R&D Directors and the Pharma Portfolio Board. Most recently he was VP and CSO of Genetics and Integrated Medicine and a member of the Roche Genetics Executive Committee.
Dr. Hosang received his M.S. and Ph.D. degrees in Biochemistry from the ETH in Zurich, and pursued his postgraduate training at Stanford University Medical School and at the University of Washington in Seattle. He currently serves as the Chairman of the Board of Directors of Unitectra AG, the joint technology transfer office of the Universities of Zurich, Bern and Basel.